Bullous pemphigoid accompanied by aplastic anemia: The induction of IL-17-producing cells in the affected areas of the skin

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Abstract

Th17 cells, characterized by IL-17 production, play a critical role in the pathogenesis of autoimmune diseases, including autoimmune bullous disorders and aplastic anemia (AA). In this report, we describe a 58-year-old Japanese man with bullous pemphigoid (BP) accompanied by AA. Interestingly, immunohistochemical staining revealed the existence of IL-17-producing cells in the skin biopsy specimens from BP. Our findings might suggest relationships between IL-17 and the pathogenesis of these autoimmune diseases, and, to our knowledge, this is the first English report of BP accompanied by AA.

Original languageEnglish
Pages (from-to)211-214
Number of pages4
JournalCase Reports in Dermatology
Volume4
Issue number3
DOIs
Publication statusPublished - 2012 Apr 20

Keywords

  • Aplastic anemia
  • Bullous pemphigoid
  • IL-17

ASJC Scopus subject areas

  • Dermatology

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