BSF‐2/IL‐6 does not augment lg secretion but stimulates proliferation in myeloma cells

Osamu Tanabe, Michio Kawano, Hideo Tanaka, Koji Iwato, Hideki Asaoku, Hideaki Ishikawa, Masaharu Nobuyoshi, Toshio Hirano, Tadamitsu Kishimoto, Atsushi Kuramoto

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

Human myeloma cells were highly purified from bone marrow aspirates of 21 patients with advanced immunoglobulin G (IgG)‐type multiple myeloma. B‐cell stimulatory factor 2 (BSF‐2)/interleukin‐6 (IL‐6) was originally characterized as a cytokine that can enhance immunoglobulin secretion from activated normal B cells and increase the expression of secretory‐type Ig mRNA in these B cells, but that does not augment proliferation of activated B cells. However, recombinant IL‐6 (rIL‐6) could not enhance M‐protein (IgG) secretion in freshly isolated myeloma cells in vitro but could augment proliferation of myeloma cells, although myeloma cells constitutively expressed IL‐6 receptors. Furthermore, expression of secretory‐type IgG (γ‐chain) mRNA in myeloma cells was not changed in the presence of IL‐6. These results show that IL‐6 is not an enhancing factor in Ig secretion from myeloma cells, and thus signal transduction through IL‐6 in myeloma cells may be altered as opposed to activated B cells.

Original languageEnglish
Pages (from-to)258-262
Number of pages5
JournalAmerican Journal of Hematology
Volume31
Issue number4
DOIs
Publication statusPublished - 1989 Jan 1

Keywords

  • IL‐6
  • Ig secretion
  • multiple myeloma
  • myeloma cell proliferation

ASJC Scopus subject areas

  • Hematology

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