Bruchpilot, A synaptic active zone protein for anesthesia-resistant memory

Stephan Knapek, Stephan Sigrist, Hiromu Tanimoto

    Research output: Contribution to journalArticle

    39 Citations (Scopus)

    Abstract

    In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.

    Original languageEnglish
    Pages (from-to)3453-3458
    Number of pages6
    JournalJournal of Neuroscience
    Volume31
    Issue number9
    DOIs
    Publication statusPublished - 2011 Mar 2

    ASJC Scopus subject areas

    • Neuroscience(all)

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