Bronchomotor agents and hysteris of collateral resistance in dog lobe

R. Kikuchi, K. Kikuchi, J. Hildebrandt, K. Sekizawa, M. Yamaya, H. Sasaki

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The effect of smooth muscle tone on hysteresis of collateral channels was examined and compared with that of airways, in freshly excised dog lobes. A double lumen catherer was sealed into a branch off the main bronchus, and air (Vs) flowed through the outer lumen while the pressure in the segment (Ps) was measured by the inner lumen. Collateral conductance (Gcoll) was calculated as Gcoll = Vs/Ps. In another series of experiments a pleural capsule was used to measure either segmental airway flow (Vsaw) or capsule pressure (Pcap). Segmental airway conductance (Gsaw) was calculated as Gsaw = Vsaw/(Ps-Pscap). Hysteresis for Gcoll vs lung volume (Vl) curves were almost absent in control and after isoproterenol inflation Gcoll was greater than deflation Gcoll at a given Vl (clockwise history). Conversely, after histamine Gcoll vs Vl curves showed a counterclockwise history. The behaviors of Gcoll and Gsaw against a bronchomotor agent were similar. We conclude that major collateral channels have muscular walls, and being that of an airway type.

Original languageEnglish
Pages (from-to)127-137
Number of pages11
JournalRespiration Physiology
Volume96
Issue number2-3
DOIs
Publication statusPublished - 1994 May

Keywords

  • Collateral ventilation, smooth muscle tone
  • Mammals, dog
  • Smooth muscle, tone, bronchial, collateral channels
  • Ventilation, collateral, smooth muscle tone

ASJC Scopus subject areas

  • Physiology
  • Pulmonary and Respiratory Medicine

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  • Cite this

    Kikuchi, R., Kikuchi, K., Hildebrandt, J., Sekizawa, K., Yamaya, M., & Sasaki, H. (1994). Bronchomotor agents and hysteris of collateral resistance in dog lobe. Respiration Physiology, 96(2-3), 127-137. https://doi.org/10.1016/0034-5687(94)90121-X