Breast Cancer Metastasis in the Skin with Hyperkeratotic Pigmentation Caused by Melanocyte Colonization

Shino Ishihara-Yusa, Taku Fujimura, Chunbing Lyu, Masayuki Sugawara, Kazuhiro Sakamoto, Setsuya Aiba

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Pigmented breast cancer in the skin caused by nonneoplastic melanocytes of epidermal origin is a rare condition of metastasis from breast cancer, but the pathogenesis of this phenomenon is almost unknown. In this report, we describe a case of breast cancer metastasis in the skin with prominent hyperkeratotic pigmentation caused by nonneoplastic melanocyte colonization. Immunohistochemical staining revealed that the metastatic tumor cells produced IL-23, which is reported not only to induce IL-17 but also to inhibit cell apoptosis in breast cancer cells, which affects tumor progression. In addition to IL-23, substantial numbers of IL-17-producing cells were detected at the peritumoral area, suggesting that IL-17 might induce not only melanogenesis but also keratinocyte proliferation and tumorigenesis. Our report suggests possible mechanisms of hyperkeratotic pigmentation of breast cancer metastasis in the skin.

Original languageEnglish
Pages (from-to)660-664
Number of pages5
JournalCase Reports in Oncology
Volume11
Issue number3
DOIs
Publication statusPublished - 2018 Sep 1

Keywords

  • Breast cancer
  • Hyperkeratosis
  • IL-17
  • IL-23
  • Melanocyte colonization

ASJC Scopus subject areas

  • Oncology

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