Break point of antimicrobial agents against respiratory tract infections in Japan

Akira Watanabe

    Research output: Contribution to journalArticlepeer-review

    3 Citations (Scopus)


    An attempt was made to determine the break point of 32 antimicrobial agents administered in Japan to 1,372 patients with respiratory tract infections which the causative pathogens, clinical effects and bacteriological effects were documented. The break point could be easily determined in chronic respiratory infections i.e. chronic bronchitis and bronchiectasis compared with acute respiratory infections i.e. acute bronchitis and acute pneumonia. The break point of β-lactams could be determined easily because the transitional zone from the susceptible to the resistant break point was limited in a narrow range. On the other hand, the break point of new-quinolones could be found only with difficulty because the transitional zone was wide. Sputum concentrations of antimicrobial agents seemed to be one of the major factors which determine the break point against respiratory infections. Although, the results obtained in this study were similar to those of NCCLS in the USA, further study is necessary to determine the precise break point against respiratory infections in Japan, because sufficient data are not yet available.

    Original languageEnglish
    Pages (from-to)1162-1168
    Number of pages7
    Issue number9
    Publication statusPublished - 1992 Jan 1

    ASJC Scopus subject areas

    • Pharmacology (medical)
    • Infectious Diseases
    • Pharmacology
    • Drug Discovery
    • Oncology


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