TY - JOUR
T1 - Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain
AU - Suzuki, Youichi
AU - Suzuki, Hiroyuki
AU - Kayama, Takamasa
AU - Yoshimoto, Takashi
AU - Shibahara, Shigeki
N1 - Copyright:
Copyright 2014 Elsevier B.V., All rights reserved.
PY - 1991/12/31
Y1 - 1991/12/31
N2 - Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder. A part of the gene for NF1 was cloned and its deduced protein has a domain functionally related to mammalian ras GTPase-activating protein (GAP). Human tissues examined express two types of NF1 mRNAs: an originally identified species of NF1 mRNA (type I) and another one containing the 63 base insert in the region coding for GAP-related domain (type II). However, relative levels of both mRNAs seem to change under certain conditions. Human brain expresses type I mRNA predominantly, while type II is preferentially expressed in most primary brain tumors ( 13 16 tumors analyzed.). We suggest that higher levels of type II mRNA may be related to the genesis of brain tumors.
AB - Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder. A part of the gene for NF1 was cloned and its deduced protein has a domain functionally related to mammalian ras GTPase-activating protein (GAP). Human tissues examined express two types of NF1 mRNAs: an originally identified species of NF1 mRNA (type I) and another one containing the 63 base insert in the region coding for GAP-related domain (type II). However, relative levels of both mRNAs seem to change under certain conditions. Human brain expresses type I mRNA predominantly, while type II is preferentially expressed in most primary brain tumors ( 13 16 tumors analyzed.). We suggest that higher levels of type II mRNA may be related to the genesis of brain tumors.
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U2 - 10.1016/0006-291X(91)92029-J
DO - 10.1016/0006-291X(91)92029-J
M3 - Article
C2 - 1662505
AN - SCOPUS:0026333880
VL - 181
SP - 955
EP - 961
JO - Biochemical and Biophysical Research Communications
JF - Biochemical and Biophysical Research Communications
SN - 0006-291X
IS - 3
ER -