Brain tumors predominantly express the neurofibromatosis type 1 gene transcripts containing the 63 base insert in the region coding for GTPase activating protein-related domain

Yoichi Suzuki, Hiroyuki Suzuki, Takamasa Kayama, Takashi Yoshimoto, Shigeki Shibahara

Research output: Contribution to journalArticle

49 Citations (Scopus)

Abstract

Neurofibromatosis type 1 (NF1) is an autosomal dominant neurocutaneous disorder. A part of the gene for NF1 was cloned and its deduced protein has a domain functionally related to mammalian ras GTPase-activating protein (GAP). Human tissues examined express two types of NF1 mRNAs: an originally identified species of NF1 mRNA (type I) and another one containing the 63 base insert in the region coding for GAP-related domain (type II). However, relative levels of both mRNAs seem to change under certain conditions. Human brain expresses type I mRNA predominantly, while type II is preferentially expressed in most primary brain tumors ( 13 16 tumors analyzed.). We suggest that higher levels of type II mRNA may be related to the genesis of brain tumors.

Original languageEnglish
Pages (from-to)955-961
Number of pages7
JournalBiochemical and biophysical research communications
Volume181
Issue number3
DOIs
Publication statusPublished - 1991 Dec 31

ASJC Scopus subject areas

  • Biochemistry
  • Biophysics
  • Molecular Biology

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