Brain tumor accumulation and plasma pharmacokinetic parameters of 2′-deoxy-5-18F-fluorouridine

Kiichi Ishiwata, Yuji Tsurumi, Motonobu Kameyama, Kiyotaka Sato, Ren Iwata, Toshihiro Takahashi, Tatsuo Ido, Takashi Yoshimoto

    Research output: Contribution to journalArticlepeer-review

    6 Citations (Scopus)

    Abstract

    Using positron emission tomography and radio-high performance liquid chromatography, the accumulation of 2′-deoxy-5-18F-fluorouridine in the brain tumors and plasma pharmacokinetic parameters were investigated in 20 patients. High accumulation of the tracer in high grade gliomas and meningiomas and very rapid degradation of the tracer in the plasma were found. Very large variations were observed in both tumor accumulation and pharmacokinetic data. The tumor accumulation, however, did not correlate with any of the plasma pharmacokinetic parameters: area under the plasma concentration-time curve, mean residence time, total body clearance and steady-state volume of distribution. The results suggest that the accumulation of the tracer reflects the metabolic activity of the brain tumor tissues and that the effect of the rapid metabolic change in the tracer in the plasma on the tumor accumulation may be minor.

    Original languageEnglish
    Pages (from-to)199-205
    Number of pages7
    JournalAnnals of Nuclear Medicine
    Volume7
    Issue number3
    DOIs
    Publication statusPublished - 1993 Sep 1

    Keywords

    • 2′-deoxy-5-F-fluorouridine
    • brain tumor
    • nucleic acid metabolism
    • pharmacokinetics
    • positron emission tomography

    ASJC Scopus subject areas

    • Radiology Nuclear Medicine and imaging

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