Brain responses to cardiac electrical stimulation: A new EEG method for evaluating cardiac sensation

Hideaki Suzuki, Masanori Hirose, Satoshi Watanabe, Koji Fukuda, Shin Fukudo, Hiroaki Shimokawa

Research output: Contribution to journalArticlepeer-review

1 Citation (Scopus)

Abstract

Although cardiac sensation, such as palpitation or chest pain, is common and is sometimes a malignant sign of heart diseases, the mechanism by which the human brain responds to afferent signals from the heart remains unclear. In this study, we investigated whether electrical stimulation of the heart provokes brain responses in humans. We examined 15 patients (age: 65.4 ± 3.1 years old, 11 males and 4 females) implanted with either a cardiac pacemaker or cardiac resynchronization therapy (CRT) device. Electroencephalogram (EEG) was simultaneously recorded from the vertex during right ventricular pacing at 70-100 beats/min at baseline (1.5 V) and intense (6-8 V) stimulation sessions. We evaluated brain responses to cardiac electrical stimulation by measuring cerebral potentials that were obtained by subtracting the average of 100 EEG waves triggered by cardiac pacing during baseline stimulation from those during the intense stimulation. Intense stimulation of the cardiac pacemaker or CRT device reproducibly induced cardiac sensation in 6 out of the 15 patients; namely, the remaining 9 patients showed no reproducible response. Brain responses were evident by averaging cerebral potentials from all of the 15 patients and those from 6 patients with reproducible cardiac sensation. To the best our knowledge, this is the irst report that demonstrates the brain responses to cardiac electrical stimulation in humans. This new method should be useful for examining pathophysiology of cardiac diseases with pathological cardiac sensation, including cardiac anxiety and silent myocardial ischemia.

Original languageEnglish
Pages (from-to)3-10
Number of pages8
JournalTohoku Journal of Experimental Medicine
Volume226
Issue number1
DOIs
Publication statusPublished - 2012

Keywords

  • Cardiac afferent nerves
  • Cardiac resynchronization therapy
  • Cardiac sensation
  • Electroencephalogram
  • Pacemaker

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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