Brain metabolic changes of cervical dystonia with spinocerebellar ataxia type 1 after botulinum toxin therapy

Akio Kikuchi, Atsushi Takeda, Naoto Sugeno, Emiko Miura, Kazuhiro Kato, Takafumi Hasegaw, Toru Baba, Masatoshi Konno, Ryuji Oshima, Shoichi Watanuki, Kotaro Hiraoka, Manabu Tashiro, Masashi Aoki

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)

Abstract

We occasionally observe long-term remission of cervical dystonia after several botulinum toxin treatments. However, botulinum toxin transiently acts on neuromuscular junctions. We herein report that a cervical dystonia patient with spinocerebellar ataxia type 1 could have long-term remission as a result of the depression of hypermetabolism in the bilateral putamen and primary sensorimotor cortex after botulinum toxin therapy. We suggest that botulinum toxin impacts the central nervous system, causing prolonged improvement through the normalization of basal ganglia circuits in addition to its effects at neuromuscular junctions.

Original languageEnglish
Pages (from-to)1919-1922
Number of pages4
JournalInternal Medicine
Volume55
Issue number14
DOIs
Publication statusPublished - 2016
Externally publishedYes

Keywords

  • Basal ganglia circuits
  • Botulinum toxin treatment
  • Cervical dystonia
  • Positron emission tomography (PET)
  • Spinocerebellar ataxia type 1 (SCA1)

ASJC Scopus subject areas

  • Internal Medicine

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