Brain magnetic resonance imaging and motor and intellectual functioning in 86 patients born at term with spastic diplegia

Yurika Numata, Akira Onuma, Yasuko Kobayashi, Ikuko Sato-Shirai, Soichiro Tanaka, Satoru Kobayashi, Keisuke Wakusawa, Takehiko Inui, Shigeo Kure, Kazuhiro Haginoya

Research output: Contribution to journalArticlepeer-review

30 Citations (Scopus)

Abstract

Aim To investigate the association between magnetic resonance imaging (MRI) patterns and motor function, epileptic episodes, and IQ or developmental quotient in patients born at term with spastic diplegia. Method Eighty-six patients born at term with cerebral palsy (CP) and spastic diplegia (54 males, 32 females; median age 20y, range 7-42y) among 829 patients with CP underwent brain MRI between 1990 and 2008. The MRI and clinical findings were analysed retrospectively. Intellectual disability was classified according to the Enjoji developmental test or the Wechsler Intelligence Scale for Children (3rd edition). Results The median ages at diagnosis of CP, assignment of Gross Motor Function Classification System (GMFCS) level, cognitive assessment, and MRI were 2years (range 5mo-8y), 6years (2y 8mo-19y), 6years (1y 4mo-19y), and 7years (10mo-30y) respectively. MRI included normal findings (41.9%), periventricular leukomalacia, hypomyelination, and porencephaly/periventricular venous infarction. The frequency of patients in GMFCS levels III to V and intellectual disability did not differ between those with normal and abnormal MRI findings. Patients with normal MRI findings had significantly fewer epileptic episodes than those with abnormal ones (p=0.001). Interpretation Varied MRI findings, as well as the presence of severe motor dysfunction and intellectual disability (despite normal MRI), suggest that patients born at term with spastic diplegia had heterogeneous and unidentified pathophysiology.

Original languageEnglish
Pages (from-to)167-172
Number of pages6
JournalDevelopmental Medicine and Child Neurology
Volume55
Issue number2
DOIs
Publication statusPublished - 2013 Feb

ASJC Scopus subject areas

  • Pediatrics, Perinatology, and Child Health
  • Developmental Neuroscience
  • Clinical Neurology

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