Brain-gut response to stress and cholinergic stimulation in irritable bowel syndrome: A preliminary study

Shin Fukudo, Taisuke Nomura, Motoyasu Muranaka, Fumihito Taguchi

Research output: Contribution to journalArticlepeer-review

99 Citations (Scopus)

Abstract

To investigate the influence of the brain-gut interactions on the pathophysiology of irritable bowel syndrome (IBS), we compared such patients (n = 10) with healthy control subjects (n = 11) by measuring the pressure of the colon and small intestine simultaneously with analysis of power spectrum of the electroencephalography (EEG) under mental stress and administration of neostigmine. Stress slightly increased the colonic motility index, reduced the percentage of alpha power, and increased the percentage of beta and theta power of the EEG in the patients with IBS more than in the controls (p < 0.05). The patients with IBS had a longer phase II (p < 0.01) and shorter phase I (p < 0.02) of fasting duodenal motor activity than the controls. Neostigmine (10 μg/kg) caused a significant difference in the colonic motility index (p < 0.01) and power spectra of EEG (p < 0.05) in the patients with IBS compared to the controls. Significant positive correlation was detected between colonic motility and power spectral change induced by stress (r = 0.46, p < 0.05) or neostigmine (r = 0.51, p < 0.01). These results suggest that patients with IBS have exaggerated responsivity of the gut and the brain to mental stress and cholinergic stimulation. Moreover, there is a possibility that these exaggerated responses are related.

Original languageEnglish
Pages (from-to)133-141
Number of pages9
JournalJournal of Clinical Gastroenterology
Volume17
Issue number2
DOIs
Publication statusPublished - 1993 Sep

Keywords

  • Brain-gut interactions
  • Colonic motility
  • Duodenal motility
  • Electroencephalography
  • Irritable bowel syndrome
  • Neostigmine
  • Power spectrum
  • Stress

ASJC Scopus subject areas

  • Gastroenterology

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