Abstract
Several lines of evidence have made brain-derived neurotrophic factor (BDNF) an important candidate gene conferring risk for Alzheimer's disease (AD). Recently, three studies reported an association between two single-nucleotide polymorphisms (SNP) - i.e., C270T and G196A - in the BDNF gene and AD. This attempt to confirm these associations in a larger AD sample included examination of the linkage disequilibrium of these two SNPs. Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046). These findings suggest that BDNF gene polymorphisms play some role in the development of AD.
Original language | English |
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Pages (from-to) | 703-711 |
Number of pages | 9 |
Journal | Journal of Neural Transmission |
Volume | 112 |
Issue number | 5 |
DOIs | |
Publication status | Published - 2005 May |
Keywords
- Alzheimer disease
- Apolipoprotein E (ApoE4)
- Brain-derived neurotrophic factor
- Case-control study, genetic association
- Single nucleotide polymorphism (SNP)
ASJC Scopus subject areas
- Neurology
- Clinical Neurology
- Psychiatry and Mental health
- Biological Psychiatry