Brain conditions mediate the association between aging and happiness

Keisuke Kokubun, Kiyotaka Nemoto, Yoshinori Yamakawa

Research output: Contribution to journalArticlepeer-review


As the population ages, the realization of a long and happy life is becoming an increasingly important issue in many societies. Therefore, it is important to clarify how happiness and the brain change with aging. In this study, which was conducted with 417 healthy adults in Japan, the analysis showed that fractional anisotropy (FA) correlated with happiness, especially in the internal capsule, corona radiata, posterior thalamic radiation, cingulum, and superior longitudinal fasciculus. According to previous neuroscience studies, these regions are involved in emotional regulation. In psychological studies, emotional regulation has been associated with improvement in happiness. Therefore, this study is the first to show that FA mediates the relationship between age and subjective happiness in a way that bridges these different fields.

Original languageEnglish
Article number4290
JournalScientific reports
Issue number1
Publication statusPublished - 2022 Dec
Externally publishedYes

ASJC Scopus subject areas

  • General


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