Brain and whole body distribution of N-isopropyl-4-iodoamphetamine (I-123) in humans: Comparison of radiopharmaceuticals marketed by different companies in Japan

Hiroshi Ito, Tachio Sato, Hayato Odagiri, Kentaro Inoue, Miho Shidahara, Tetsuya Suhara, Jun Hatazawa, Hiroshi Fukuda

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Objective: Iodine-123 (123I)-labeled N-isopropyl-4- iodoamphetamine (IMP) has been used as a cerebral blood flow (CBF) tracer for single-photon emission computed tomography (SPECT). An autoradiographic (ARG) method has been developed for the quantitation of CBF by IMP and SPECT. Two IMPs (IMPA and IMPB) produced by different radiopharmaceutical companies are marketed in Japan. In the present study, whole-body distributions including brain and blood of the two IMPs were compared in the same human subjects. Methods: Two brain SPECT studies using IMPA or IMP B were performed on separate days in six young healthy men. Whole-body scans were also obtained with a large field-of-view single-head gamma camera. One-point arterial blood sampling was performed at 10 min after injection of IMP to measure both the radioactivity concentrations of whole blood and of octanol-extracted components. Results: No significant differences between the two tracers were observed in body distribution, tracer kinetics in brain, or regional distribution in brain. However, the octanol extraction fraction in blood was significantly different between the two tracers. Radiochemical purity was slightly but significantly different between the tracers. Conclusions: In the ARG method, arterial input function is determined by calibration of a standard input function with the radioactivity concentration of arterial whole blood. Because the standard input function in the ARG method was obtained using IMPA, the standard input function obtained for IMPB should be used when CBF is calculated by the ARG method with IMPB.

Original languageEnglish
Pages (from-to)493-498
Number of pages6
JournalAnnals of Nuclear Medicine
Volume20
Issue number7
DOIs
Publication statusPublished - 2006 Jan 1

Keywords

  • ARG method
  • CBF
  • IMP
  • SPECT

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging

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