Brain 6-[18F]fluorodopa metabolism in early and late onset of Parkinson's disease studied by positron emission tomography

Haruo Nagasawa, Hiroaki Tanji, Yasuto Itoyama, Hiroshi Saito, Itaru Kimura, Takehiko Fujiwara, Ren Iwata, Masatoshi Itoh, Tatsuo Ido

Research output: Contribution to journalArticlepeer-review

13 Citations (Scopus)

Abstract

We measured 6-[18F]fluorodopa (FDOPA) uptake in the caudate nucleus and the putamen of 20 patients with early and late onset of Parkinson's disease (EOPD and LOPD) and 20 normal control subjects using positron emission tomography. The mean influx rate constant values (K(i)) were significantly reduced in the caudate nucleus and the putamen of the patients with EOPD and LOPD compared with age-matched control groups (p < 0.01), respectively. There were significant negative correlations between K(i) values in the caudate nucleus (r = - 0.67, p = 0.0024) and the putamen (r = - 0.67, p = 0.0014), and duration of disease in the LOPD group compared with the EOPD group. Similar negative relationships between K(i) values and clinical stages by Hoehn and Yahr and degrees of main clinical symptoms (bradykinesia, tremor and rigidity) were more markedly seen in the LOPD group than in the EOPD group. The present results suggest that the function of presynaptic dopaminergic terminals correlates well with clinical disease severity and degrees of main symptoms in the LOPD group, but not in the EOPD group. We speculate that compensatory up-regulatory function in the postsynaptic dopaminergic receptors may modify disease severity and the degrees of main clinical symptoms of EOPD.

Original languageEnglish
Pages (from-to)70-76
Number of pages7
JournalJournal of the neurological sciences
Volume144
Issue number1-2
DOIs
Publication statusPublished - 1996 Dec

Keywords

  • 6-[F]fluorodopa metabolism
  • early and late onset Parkinson's disease
  • nigrostriatal system
  • positron emission tomography

ASJC Scopus subject areas

  • Neurology
  • Clinical Neurology

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