Bradykinin B2 antagonist HOE 140 inhibits late allergic microvascular leakage in guinea pig airways

Yasufumi Mashito, Masakazu Ichinose, Kunio Shirato

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

Because bradykinin has potent inflammatory actions, this molecule may be involved in the late allergic response (LAR). We investigated the role of the molecule in airway microvascular hyperpermeability during the LAR. Three weeks after ovalbumin (OVA) sensitization, animals were pretreated with bradykinin B2 receptor antagonist HOE 140 or vehicle for 30 min before the OVA inhalation challenge. The occurrence of LAR was judged by a two-fold increase in transpulmonary pressure (P(tp)) from the baseline values. The microvascular permeability in the trachea was assessed by an index defined as the ratio of the area of vasculature labeled by the Monastral blue dye (area density percent). Significant microvascular hyperpermeability were observed during the LAR. The bradykinin concentrations in the bronchoalveolar lavage-fluid (BAL-f) were increased during the LAR. HOE 140 (0.1-10 mg/kg, s.c.) inhibited the airway microvascular hyperpermeability during the LAR dose-dependently. These findings suggest that bradykinin may play an important role in microvascular hyperpermeability during the LAR. Copyright (C) 1999 Elsevier Science B.V.

Original languageEnglish
Pages (from-to)249-253
Number of pages5
JournalImmunopharmacology
Volume43
Issue number2-3
DOIs
Publication statusPublished - 1999 Sep

Keywords

  • Airway inflammation
  • Asthma
  • Bradykinin

ASJC Scopus subject areas

  • Pharmacology

Fingerprint Dive into the research topics of 'Bradykinin B<sub>2</sub> antagonist HOE 140 inhibits late allergic microvascular leakage in guinea pig airways'. Together they form a unique fingerprint.

Cite this