Boundary element analysis of deformation and movement of a capsule and a red blood cell close to the wall

S. Nix, Yohsuke Imai, Takuji Ishikawa, Takami Yamaguchi

Research output: Contribution to journalConference article

Abstract

Acapsuleis definedas aliquiddropenclosedbyanelastic membrane. Thestudyof capsule behavior near a stationary surface has a numberof biological applications, such as red blood cells in the cardiovascular system. However, near-wall behavior of capsules has not been established well. In this study, we investigate the motion of initially spherical and biconcave capsules in simple shear flow near an infinite plane using a boundary integral method coupled to a finite element method. We find that the deformation of a capsule depends on its initial shape, orientation, and capillary number (Ca). However, the lift velocity of a capsule is dependent on its steady state deformation and distance from the wall. The dependence of lift velocity on deformation may help to explain phenomena such as leukocyte margination.

Original languageEnglish
Pages (from-to)191-199
Number of pages9
JournalWIT Transactions on Modelling and Simulation
Volume53
DOIs
Publication statusPublished - 2012 Nov 29
Event34th International Conference on Boundary Elements and other Mesh Reduction Methods - BEM/MRM 2012, BE12 - Split, Croatia
Duration: 2012 Jul 252012 Jul 27

Keywords

  • Boundary integral method
  • Capsule flow
  • Finite element method
  • Lateral migration

ASJC Scopus subject areas

  • Modelling and Simulation
  • Computational Mathematics

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