Boronic Acid Ligands Can Target Multiple Subpopulations of Pancreatic Cancer Stem Cells via pH-Dependent Glycan-Terminal Sialic Acid Recognition

Takuya Miyazaki, Thahomina Khan, Yoshihiro Tachihara, Michiko Itoh, Taiki Miyazawa, Takayoshi Suganami, Yuji Miyahara, Horacio Cabral, Akira Matsumoto

Research output: Contribution to journalArticlepeer-review

Abstract

Eradication of cancer stem cells (CSCs) is an ultimate goal in cancer chemotherapy. Although a ligand-assisted targeting approach seems rational, the existence of subpopulations of CSCs and their discrimination from those present on healthy sites makes it a severe challenge. Some boronic acid (BA) derivatives are known for the ability to bind with glycan-terminal sialic acid (SA), in a manner dependent on the acidification found in hypoxic tumoral microenvironment. Taking advantage of this feature, here we show that the BA-ligand fluorescence conjugate can effectively target multiple CSC subpopulations in parallel, which otherwise must be independently aimed when using antibody-ligands.

Original languageEnglish
JournalACS Applied Bio Materials
DOIs
Publication statusAccepted/In press - 2021

Keywords

  • active targeting
  • boronic acids
  • cancer stem cells
  • pancreatic cancer
  • sialic acids
  • stimuli-response

ASJC Scopus subject areas

  • Chemistry(all)
  • Biomaterials
  • Biomedical Engineering
  • Biochemistry, medical

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