Bonelike apatite formation on ethylene-vinyl alcohol copolymer modified with silane coupling agent and calcium silicate solutions

Ayako Oyane, Masakazu Kawashita, Kazuki Nakanishi, Tadashi Kokubo, Masahiko Minoda, Takeaki Miyamoto, Takashi Nakamura

Research output: Contribution to journalArticlepeer-review

112 Citations (Scopus)

Abstract

An ethylene-vinyl alcohol copolymer (EVOH) was treated with a silane coupling agent and calcium silicate solutions, and then soaked in a simulated body fluid (SBF) with ion concentrations approximately equal to those of human blood plasma. A smooth and uniform bonelike apatite layer was successfully formed on both the EVOH plate and the EVOH-knitted fibers in SBF within 2 days. Part of the structure of the resulting apatite-EVOH fiber composite was similar to that of natural bone. If this kind of composite can be fabricated into a three-dimensional structure similar to natural bone, the resultant composite is expected to exhibit both mechanical properties analogous to those of natural bone and bone-bonding ability. Hence, it has great potential as a bone substitute.

Original languageEnglish
Pages (from-to)1729-1735
Number of pages7
JournalBiomaterials
Volume24
Issue number10
DOIs
Publication statusPublished - 2003 May

Keywords

  • Apatite
  • Biomimetic process
  • Calcium silicate
  • Ethylene-vinyl alcohol copolymer
  • Silane coupling agent

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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