Bone marrow-derived cells contribute to lung regeneration after elastase-induced pulmonary emphysema

Kota Ishizawa, Hiroshi Kubo, Mitsuhiro Yamada, Seiichi Kobayashi, Muneo Numasaki, Shinsaku Ueda, Takashi Suzuki, Hidetada Sasaki

Research output: Contribution to journalArticle

206 Citations (Scopus)

Abstract

All-trans retinoic acid (ATRA) is known to reverse the anatomic and physiologic signs of pulmonary emphysema. However, the origin of the progenitor cells involved in this lung regeneration remains unclear. Recently, it was shown that bone marrow could be the source of progenitor cells for several cell types. Mice with elastase-induced emphysema were treated with ATRA, granulocyte colony-stimulating factor (G-CSF), or a combination of both. ATRA or G-CSF promoted lung regeneration and increased bone marrow-derived cell (BMC) numbers in alveoli. Combined treatment of both had an additive effect, which indicated that BMC mobilization might be important in lung regeneration.

Original languageEnglish
Pages (from-to)249-252
Number of pages4
JournalFEBS Letters
Volume556
Issue number1-3
DOIs
Publication statusPublished - 2004 Jan 2

Keywords

  • Bone marrow
  • Granulocyte colony-stimulating factor
  • Progenitor cell
  • Pulmonary emphysema
  • Regeneration

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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