Bone marrow aplasia with prominent atypical plasmacytic proliferation preceding acute lymphoblastic leukemia

Masahiro Kikuchi, Akimichi Ohsaka, Yasushi Chiba, Mariko Sato, Yasushi Muraosa, Hisao Hoshino

Research output: Contribution to journalArticlepeer-review

5 Citations (Scopus)

Abstract

A two-year-old boy presented with pancytopenia. Bone marrow examination revealed an aplastic marrow with prominent immature plasma cell proliferation, which mimicked plasma cell leukemia. Immunohistochemistry, however, revealed a polyclonal population consistent with a reactive process, excluding plasma cell neoplasia. Administration of granulocyte-colony stimulating factor resulted in recovery of normal hematopoiesis with resolution of plasmacytosis. Seven months later, the patient had an elevated white blood cell count and bone marrow findings diagnostic of acute lymphoblastic leukemia. To the best of our knowledge this is the first reported case of bone marrow aplasia with prominent polyclonal plasmacytosis presenting as a prodrome of acute lymphoblastic leukemia in childhood.

Original languageEnglish
Pages (from-to)213-217
Number of pages5
JournalLeukemia and Lymphoma
Volume35
Issue number1-2
DOIs
Publication statusPublished - 1999
Externally publishedYes

Keywords

  • Acute lymphoblastic leukemia
  • Bone marrow aplasia
  • Plasma cell leukemia
  • Polyclonal plasmacytosis
  • Preleukemia

ASJC Scopus subject areas

  • Hematology
  • Oncology
  • Cancer Research

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