Bone induction by controlled release of BMP-2 from a biodegradable hydrogel in various animal species -from mouse to non-human primate

Masaya Yamamoto, Yoshitake Takahashi, Yasuhiko Tabata

Research output: Contribution to journalArticlepeer-review

3 Citations (Scopus)

Abstract

The objective of this study is to examine feasibility of biodegradable gelatin hydrogels incorporating bone morphogenetic protein (BMP)-2 in inducing bone regeneration at a bone defect of non-human primates and rabbits considering their BMP-2 release profiles. As a result, controlled release by the hydrogel system enabled BMP-2 to induce successful bone regeneration in non-human primates even at the BMP-2 dose as low as that for rabbit case (0.034 mg of BMP-2/cm3 of hydrogel).

Original languageEnglish
Pages (from-to)253-256
Number of pages4
JournalKey Engineering Materials
Volume288-289
DOIs
Publication statusPublished - 2005
Externally publishedYes

Keywords

  • Biodegradable hydrogel
  • Bone morphogenetic protein
  • Bone regeneration
  • Controlled release

ASJC Scopus subject areas

  • Materials Science(all)
  • Mechanics of Materials
  • Mechanical Engineering

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