Bone demineralization following urinary intestinal diversion assessed by urinary pyridinium cross-links and dual energy x-ray absorptiometry

Mutsushi Kawakita, Yoichi Arai, Chohei Shigeno, Akito Terai, Yusaku Okada, Hideo Takeuchi, Junji Konishi, Osamu Yoshida

Research output: Contribution to journalArticlepeer-review

39 Citations (Scopus)

Abstract

Purpose: We investigated the acid-base balance and bone mineral status in patients with 3 types of urinary intestinal diversion. Materials and Methods: Of 46 men with urinary intestinal diversions 20 had a Kock pouch, 15 had an Indiana pouch and 11 had an ileal conduit. Acid-base balance was assessed by arterial blood gas analysis. Bone mineral status was measured by urinary pyridinium cross-links and dual energy x-ray absorptiometry. In addition, urinary deoxypyridinoline was measured in 79 patients. Results: Of the 46 patients 7 (15%) with the Kock pouch (1), Indiana pouch (5) and ileal conduit (1) had metabolic acidosis associated with significantly lower bone mineral densities (p <0.05) and higher urinary pyridinium cross-links (p <0.005) than did those with normal acid-base status. No difference was found in metabolic acidosis and bone demineralization among the 3 groups. Additionally, in 79 patients urinary deoxypyridinoline reached the highest level immediately postoperatively and then gradually decreased to the stable level within 1 or 2 years. Conclusions: Metabolic acidosis following urinary intestinal diversion results in bone demineralization. The types of diversion did not cause differences in metabolic acidosis and bone resorption. Bone has a major role in buffering acid overload in the early postoperative period.

Original languageEnglish
Pages (from-to)355-359
Number of pages5
JournalJournal of Urology
Volume156
Issue number2
DOIs
Publication statusPublished - 1996 Jan 1

Keywords

  • Acidosis; bone density; absorptiometry
  • Photon; pyridinium compounds; Urinary diversion

ASJC Scopus subject areas

  • Urology

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