TY - JOUR
T1 - Body mass index and mortality from all causes and major causes in Japanese
T2 - Results of a Pooled analysis of 7 large-scale cohort studies
AU - Sasazuki, Shizuka
AU - Inoue, Manami
AU - Tsuji, Ichiro
AU - Sugawara, Yumi
AU - Tamakoshi, Akiko
AU - Matsuo, Keitaro
AU - Wakai, Kenji
AU - Nagata, Chisato
AU - Tanaka, Keitaro
AU - Mizoue, Tetsuya
AU - Tsugane, Shoichiro
AU - Inoue, Manami
AU - Sasazuki, Shizuka
AU - Iwasaki, Motoki
AU - Otani, Tetsuya
AU - Sawada, Norie
AU - Shimazu, Taichi
AU - Yamaji, Taichi
AU - Tsuji, Ichiro
AU - Tsubono, Yoshitaka
AU - Nishino, Yoshikazu
AU - Matsuo, Keitaro
AU - Nagata, Chisato
AU - Mizoue, Tetsuya
AU - Tanaka, Keitaro
PY - 2011/1/1
Y1 - 2011/1/1
N2 - Background: We pooled data from 7 ongoing cohorts in Japan involving 353 422 adults (162 092 men and 191 330 women) to quantify the effect of body mass index (BMI) on total and cause-specific (cancer, heart disease, and cerebrovascular disease) mortality and identify optimal BMI ranges for middle-aged and elderly Japanese. Methods: During a mean follow-up of 12.5 years, 41 260 deaths occurred. The Cox proportional hazards model was used to estimate hazard ratios (HRs) for each BMI category, after controlling for age, area of residence, smoking, drinking, history of hypertension, diabetes, and physical activity in each study. A random-effects model was used to obtain summary measures. Results: A reverse-J pattern was seen for all-cause and cancer mortality (elevated risk only for high BMI in women) and a U- or J-shaped association was seen for heart disease and cerebrovascular disease mortality. For total mortality, as compared with a BMI of 23 to 25, the HR was 1.78 for 14 to 19, 1.27 for 19 to 21, 1.11 for 21 to 23, and 1.36 for 30 to 40 in men, and 1.61 for 14 to 19, 1.17 for 19 to 21, 1.08 for 27 to 30, and 1.37 for 30 to 40 in women. High BMI (≥27) accounted for 0.9% and 1.5% of total mortality in men and women, respectively. Conclusions: The lowest risk of total mortality and mortality from major causes of disease was observed for a BMI of 21 to 27 kg/m2in middle-aged and elderly Japanese.
AB - Background: We pooled data from 7 ongoing cohorts in Japan involving 353 422 adults (162 092 men and 191 330 women) to quantify the effect of body mass index (BMI) on total and cause-specific (cancer, heart disease, and cerebrovascular disease) mortality and identify optimal BMI ranges for middle-aged and elderly Japanese. Methods: During a mean follow-up of 12.5 years, 41 260 deaths occurred. The Cox proportional hazards model was used to estimate hazard ratios (HRs) for each BMI category, after controlling for age, area of residence, smoking, drinking, history of hypertension, diabetes, and physical activity in each study. A random-effects model was used to obtain summary measures. Results: A reverse-J pattern was seen for all-cause and cancer mortality (elevated risk only for high BMI in women) and a U- or J-shaped association was seen for heart disease and cerebrovascular disease mortality. For total mortality, as compared with a BMI of 23 to 25, the HR was 1.78 for 14 to 19, 1.27 for 19 to 21, 1.11 for 21 to 23, and 1.36 for 30 to 40 in men, and 1.61 for 14 to 19, 1.17 for 19 to 21, 1.08 for 27 to 30, and 1.37 for 30 to 40 in women. High BMI (≥27) accounted for 0.9% and 1.5% of total mortality in men and women, respectively. Conclusions: The lowest risk of total mortality and mortality from major causes of disease was observed for a BMI of 21 to 27 kg/m2in middle-aged and elderly Japanese.
KW - Body mass index
KW - Cancer
KW - Cerebrovascular disease
KW - Heart disease
KW - Mortality
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U2 - 10.2188/jea.JE20100180
DO - 10.2188/jea.JE20100180
M3 - Article
C2 - 21908941
AN - SCOPUS:84862908571
VL - 21
SP - 417
EP - 430
JO - Journal of Epidemiology
JF - Journal of Epidemiology
SN - 0917-5040
IS - 6
ER -