BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka, Nobutaka Hanagata

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)

    Abstract

    Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

    Original languageEnglish
    Article number065003
    JournalScience and Technology of Advanced Materials
    Volume12
    Issue number6
    DOIs
    Publication statusPublished - 2011 Dec

    Keywords

    • bone
    • bone morphological protein-2 (BMP-2)
    • osteoblasts
    • silica nanotube

    ASJC Scopus subject areas

    • Materials Science(all)

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