BMP-2-loaded silica nanotube fibrous meshes for bone generation

Song Chen, Xuetao Shi, Hiromi Morita, Jie Li, Nobuhiro Ogawa, Toshiyuki Ikoma, Satoshi Hayakawa, Yuki Shirosaki, Akiyoshi Osaka, Nobutaka Hanagata

    Research output: Contribution to journalArticlepeer-review

    13 Citations (Scopus)


    Silica nanotube fibrous meshes were fabricated as multiple functional matrices for both delivering bone morphological protein-2 (BMP-2) and supporting osteoblast attachment and proliferation. The meshes were fabricated via a collagen-templated sol-gel route and consisted of tubular silica with open ends. BMP-2 was loaded to the meshes by soaking in BMP-2 solution. The meshes effectively enabled the attachment and proliferation of osteoblast MC3T3-E1 cells and delivered bioactive BMP-2 to stimulate cell differentiation. These results demonstrate the potential use of the meshes in bone generation applications.

    Original languageEnglish
    Article number065003
    JournalScience and Technology of Advanced Materials
    Issue number6
    Publication statusPublished - 2011 Dec


    • bone
    • bone morphological protein-2 (BMP-2)
    • osteoblasts
    • silica nanotube

    ASJC Scopus subject areas

    • Materials Science(all)


    Dive into the research topics of 'BMP-2-loaded silica nanotube fibrous meshes for bone generation'. Together they form a unique fingerprint.

    Cite this