Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy

K. Yoshioka, S. Kino, Y. Matsuura

Research output: Chapter in Book/Report/Conference proceedingConference contribution

2 Citations (Scopus)

Abstract

For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of a QCL as a light source and a hollow-optical fiber as a beam delivery medium is developed. Firstly the measurement sensitivity of the system is evaluated by using glucose solutions and the result shows a significant correlation between optical absorbance and solution concentration. It is also confirmed that the system has a sensitivity that is enough for blood glucose measurement. Then optical absorption of human lips in the mid-infrared wavelength region is measured using a QCL with a wavenumber of 1080 cm-1 where human tissue exhibits strong absorption of glucose and its metabolites. As a result, the measured absorption follows the change of blood glucose well with a time delay of around 10 minutes and correlation factor between the absorbance and the blood glucose level is 0.42.

Original languageEnglish
Title of host publicationOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
EditorsIsrael Gannot, Israel Gannot
PublisherSPIE
ISBN (Electronic)9781510614611
DOIs
Publication statusPublished - 2018 Jan 1
EventOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018 - San Francisco, United States
Duration: 2018 Jan 272018 Jan 28

Publication series

NameProgress in Biomedical Optics and Imaging - Proceedings of SPIE
Volume10488
ISSN (Print)1605-7422

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018
CountryUnited States
CitySan Francisco
Period18/1/2718/1/28

Keywords

  • ATR spectroscopy
  • blood glucose
  • hollow-optical fiber
  • quantum cascade laser

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

Fingerprint Dive into the research topics of 'Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy'. Together they form a unique fingerprint.

  • Cite this

    Yoshioka, K., Kino, S., & Matsuura, Y. (2018). Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy. In I. Gannot, & I. Gannot (Eds.), Optical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII [104880D] (Progress in Biomedical Optics and Imaging - Proceedings of SPIE; Vol. 10488). SPIE. https://doi.org/10.1117/12.2288131