Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion

Mitsuyoshi Ichihara, Kazuaki Sasaki, Shin Ichiro Umemura, Miki Kushima, Takashi Okai

Research output: Contribution to journalArticlepeer-review

27 Citations (Scopus)

Abstract

This study investigated the induction of tissue necrosis by arterial blood flow occlusion using ultrasound image-guided high-intensity focused ultrasound (HIFU). We constructed a prototype HIFU transducer in combination with an imaging probe that provided color Doppler imaging and ultrasound contrast imaging. The HIFU beam was aimed into a branch of the renal artery in vivo. The renal artery branches of eight rabbits were occluded by HIFU at an intensity of 4 kW/cm2 (from 2 to 10 times of each sonication for 5 s). When the HIFU exposure was successful, complete cessation of blood flow was observed by color Doppler imaging with success rate of 100% (8/8). Furthermore, lack of perfusion was observed in the renal cortex with a contrast-enhanced image. Postmortem histologic evaluation showed a wedge-shaped area of infarction in six of seven cases, corresponding to the lack of the contrast medium in the ultrasound image. These results demonstrated that ultrasound image-guided HIFU can be used to induce arterial occlusion, thus producing infarction and necrosis of the perfused tissue. (E-mail: m_itihara@hotmail.com).

Original languageEnglish
Pages (from-to)452-459
Number of pages8
JournalUltrasound in Medicine and Biology
Volume33
Issue number3
DOIs
Publication statusPublished - 2007 Mar 1

Keywords

  • Arterial occlusion
  • Blood vessels
  • Contrast-Enhanced ultrasound
  • High-Intensity focused ultrasound (HIFU)
  • Microbubble
  • Optison™
  • Rabbit
  • Ultrasound

ASJC Scopus subject areas

  • Biophysics
  • Radiological and Ultrasound Technology
  • Acoustics and Ultrasonics

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