TY - JOUR
T1 - Blood flow occlusion via ultrasound image-guided high-intensity focused ultrasound and its effect on tissue perfusion
AU - Ichihara, Mitsuyoshi
AU - Sasaki, Kazuaki
AU - Umemura, Shin Ichiro
AU - Kushima, Miki
AU - Okai, Takashi
N1 - Funding Information:
This work was supported in part by grants in aid for scientific research from the Ministry of Education, Science, Sports and Culture of Japan (no.15200042) and in the Research and Development Committee Program of JSUM. The authors thank Mr Takashi Azuma of the Central Research Laboratory, Hitachi, Ltd, and Miss Tomoko Akabane, of the First Internal Medicine of Showa University School of Medicine, for technical support.
PY - 2007/3
Y1 - 2007/3
N2 - This study investigated the induction of tissue necrosis by arterial blood flow occlusion using ultrasound image-guided high-intensity focused ultrasound (HIFU). We constructed a prototype HIFU transducer in combination with an imaging probe that provided color Doppler imaging and ultrasound contrast imaging. The HIFU beam was aimed into a branch of the renal artery in vivo. The renal artery branches of eight rabbits were occluded by HIFU at an intensity of 4 kW/cm2 (from 2 to 10 times of each sonication for 5 s). When the HIFU exposure was successful, complete cessation of blood flow was observed by color Doppler imaging with success rate of 100% (8/8). Furthermore, lack of perfusion was observed in the renal cortex with a contrast-enhanced image. Postmortem histologic evaluation showed a wedge-shaped area of infarction in six of seven cases, corresponding to the lack of the contrast medium in the ultrasound image. These results demonstrated that ultrasound image-guided HIFU can be used to induce arterial occlusion, thus producing infarction and necrosis of the perfused tissue. (E-mail: m_itihara@hotmail.com).
AB - This study investigated the induction of tissue necrosis by arterial blood flow occlusion using ultrasound image-guided high-intensity focused ultrasound (HIFU). We constructed a prototype HIFU transducer in combination with an imaging probe that provided color Doppler imaging and ultrasound contrast imaging. The HIFU beam was aimed into a branch of the renal artery in vivo. The renal artery branches of eight rabbits were occluded by HIFU at an intensity of 4 kW/cm2 (from 2 to 10 times of each sonication for 5 s). When the HIFU exposure was successful, complete cessation of blood flow was observed by color Doppler imaging with success rate of 100% (8/8). Furthermore, lack of perfusion was observed in the renal cortex with a contrast-enhanced image. Postmortem histologic evaluation showed a wedge-shaped area of infarction in six of seven cases, corresponding to the lack of the contrast medium in the ultrasound image. These results demonstrated that ultrasound image-guided HIFU can be used to induce arterial occlusion, thus producing infarction and necrosis of the perfused tissue. (E-mail: m_itihara@hotmail.com).
KW - Arterial occlusion
KW - Blood vessels
KW - Contrast-Enhanced ultrasound
KW - High-Intensity focused ultrasound (HIFU)
KW - Microbubble
KW - Optison™
KW - Rabbit
KW - Ultrasound
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U2 - 10.1016/j.ultrasmedbio.2006.08.016
DO - 10.1016/j.ultrasmedbio.2006.08.016
M3 - Article
C2 - 17208351
AN - SCOPUS:33847026884
VL - 33
SP - 452
EP - 459
JO - Ultrasound in Medicine and Biology
JF - Ultrasound in Medicine and Biology
SN - 0301-5629
IS - 3
ER -