Blood Compatibility Evaluation of Elastic Gelatin Gel from Salmon Collagen

Nobuhiro Nagai, Ryosuke Kubota, Ryohei Okahashi, Masanobu Munekata

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

Blood compatibility of a novel elastic gelatin gel (e-gel) from salmon collagen was evaluated. After a 10-min incubation of the e-gel with rat whole blood, there was a macroscopically small thrombus formation on the e-gel. Microscopic observation revealed that few platelets had adhered to the e-gel. Furthermore, the platelet adhesion rate was markedly lower on the e-gel compared to collagen-coated and fibrinogen-coated surfaces. Comparable results were obtained with re-crosslinked e-gel. In conclusion, the e-gel demonstrated good blood compatibility.

Original languageEnglish
Pages (from-to)412-415
Number of pages4
JournalJournal of Bioscience and Bioengineering
Volume106
Issue number4
DOIs
Publication statusPublished - 2008 Oct 1
Externally publishedYes

Keywords

  • blood compatibility
  • elastic gel
  • platelet adhesion
  • salmon collagen

ASJC Scopus subject areas

  • Biotechnology
  • Bioengineering
  • Applied Microbiology and Biotechnology

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