Abstract
Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both 3H-cholesterol and 14C- trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3′-gallate (TF3′G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3′-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.
Original language | English |
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Pages (from-to) | 8591-8595 |
Number of pages | 5 |
Journal | Journal of Agricultural and Food Chemistry |
Volume | 58 |
Issue number | 15 |
DOIs | |
Publication status | Published - 2010 Aug 11 |
Keywords
- Black-tea polyphenols
- cholesterol absorption
- rats
- theaflavins
ASJC Scopus subject areas
- Chemistry(all)
- Agricultural and Biological Sciences(all)