Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats

Ikuo Ikeda; Takashi Yamahira; Masaki Kato; Ayako Ishikawa

doi:10.1021/jf1015285

Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats

Ikuo Ikeda, Takashi Yamahira, Masaki Kato, Ayako Ishikawa

AGR - Bioscience and Biotechnology for Future Bioindustries

Research output: Contribution to journal › Article › peer-review

53 Citations (Scopus)

Abstract

Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both ³H-cholesterol and ¹⁴C- trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3′-gallate (TF3′G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3′-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.

Original language	English
Pages (from-to)	8591-8595
Number of pages	5
Journal	Journal of Agricultural and Food Chemistry
Volume	58
Issue number	15
DOIs	https://doi.org/10.1021/jf1015285
Publication status	Published - 2010 Aug 11

Keywords

Black-tea polyphenols
cholesterol absorption
rats
theaflavins

ASJC Scopus subject areas

Chemistry(all)
Agricultural and Biological Sciences(all)

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title = "Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats",

abstract = "Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both 3H-cholesterol and 14C- trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3′-gallate (TF3′G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3′-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.",

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author = "Ikuo Ikeda and Takashi Yamahira and Masaki Kato and Ayako Ishikawa",

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doi = "10.1021/jf1015285",

language = "English",

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AU - Ikeda, Ikuo

AU - Yamahira, Takashi

AU - Kato, Masaki

AU - Ishikawa, Ayako

PY - 2010/8/11

Y1 - 2010/8/11

N2 - Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both 3H-cholesterol and 14C- trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3′-gallate (TF3′G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3′-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.

AB - Administration of black-tea polyphenols (BTP) simultaneously reduced lymphatic recovery of both 3H-cholesterol and 14C- trioleoylglycerol in rats that were cannulated in the thoracic duct. BTP decreased the in vitro micellar solubility of cholesterol in a dose-dependent manner. When purified theaflavins, which are components of BTP, were used, theaflavin-monogallates (TFMGs), theaflavin-3-gallate (TF3G), and theaflavin-3′-gallate (TF3′G) were effective in eliminating cholesterol from bile salt micelles in vitro. Theaflavin (TF) and theaflavin-3,3′-digallate (TFDG) had no effect on the micellar solubility of cholesterol. The concentration of bile acid in the micelles was not influenced by the addition of any BTPs or theaflavins. These results suggest that the reduction of micellar cholesterol by BTP could be important to reducing cholesterol absorption.

KW - Black-tea polyphenols

KW - cholesterol absorption

KW - rats

KW - theaflavins

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Black-tea polyphenols decrease micellar solubility of cholesterol in vitro and intestinal absorption of cholesterol in rats

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Keywords

ASJC Scopus subject areas

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