Bis(methylmercuric) selenide as a reaction product from methylmercury and selenite in rabbit blood

Akira Naganuma, N. Imura

Research output: Contribution to journalArticlepeer-review

76 Citations (Scopus)

Abstract

The compound formed by the reaction of methylmercury and selenite in rabbit blood was characterized. When methylmercuric chloride (10 nmol) and sodium selenite (10 nmol) were added to rabbit blood (1 ml), about 6.5 nmol of mercury and 3.2 nmol of selenium were extracted with benzene. Mercury and selenium thus transferred into benzene at the molar ratio of 2:1 were confirmed to form a single compound which was identified as bis(methylmercuric) selenide: (CH3Hg)2Se. The formation of (CH3Hg)2Se from methylmercury and selenite in blood, presumably by the participation of glutathione (GSH), might play a role in the protective effect of selenium against methylmercury toxicity.

Original languageEnglish
Pages (from-to)163-173
Number of pages11
JournalResearch Communications in Chemical Pathology and Pharmacology
Volume27
Issue number1
Publication statusPublished - 1980 Jan 1

ASJC Scopus subject areas

  • Pathology and Forensic Medicine
  • Toxicology
  • Pharmacology
  • Pharmacology, Toxicology and Pharmaceutics(all)

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