TY - JOUR
T1 - Bipolar Radiofrequency Ablation of the Adrenal Gland
T2 - In Vivo and Ex Vivo Experiments
AU - Kinoshita, Tomo
AU - Seiji, Kazumasa
AU - Oguro, Sota
AU - Ono, Yoshikiyo
AU - Morimoto, Ryo
AU - Satoh, Fumitoshi
AU - Takase, Kei
N1 - Funding Information:
The authors wish to thank all individuals involved in this study for their support. The authors are also grateful to Makoto Inaba and his colleagues (Olympus Medical Systems Corp., Tokyo, Japan) for their contribution. This research was supported by AMED under Grant Number JP20hk0102060.
Publisher Copyright:
© 2023 Tohoku University Medical Press.
PY - 2023
Y1 - 2023
N2 - Laparoscopic adrenalectomy is currently the standard treatment modality for unilateral aldosteroneproducing adenoma (APA); however, a less-invasive treatment is needed for its treatment. A new bipolar ablation system that poses a lower risk of complications has been recently developed. This study aimed to evaluate the safety and performance of a novel bipolar radiofrequency ablation (RFA) system for the treatment of APAs. Ablations were performed in an ex vivo study using bovine adrenal glands [group A: n = 6, single-probe; group B: n = 6, two probes, interprobe distance (ID) = 12 mm; group C: n = 6, two probes, ID = 20 mm]. The in vivo study was conducted in groups A and B (n = 2 each) using porcine adrenal glands. For the ex vivo study, the mean vertical diameter (Dv) of the coagulative necrosis area and the mean transverse diameter (Dt) values were 11.99 mm and 10.96 mm for group A, 12.66 mm and 10.0 mm for group B, and 23.37 mm and 22.10 mm for group C, respectively. For the in vivo study, the mean Dv and Dt values were 12.23 mm and 9.03 mm for group A, and 16.38 mm and 9.52 mm for group B, respectively. No heat-induced damage to the adjacent organs was observed. To our best knowledge, this is the first study to evaluate the performance of the bipolar system in RFA of the adrenal gland. RFA using the new bipolar ablation system is safe and produces a sufficient coagulation area to treat APAs.
AB - Laparoscopic adrenalectomy is currently the standard treatment modality for unilateral aldosteroneproducing adenoma (APA); however, a less-invasive treatment is needed for its treatment. A new bipolar ablation system that poses a lower risk of complications has been recently developed. This study aimed to evaluate the safety and performance of a novel bipolar radiofrequency ablation (RFA) system for the treatment of APAs. Ablations were performed in an ex vivo study using bovine adrenal glands [group A: n = 6, single-probe; group B: n = 6, two probes, interprobe distance (ID) = 12 mm; group C: n = 6, two probes, ID = 20 mm]. The in vivo study was conducted in groups A and B (n = 2 each) using porcine adrenal glands. For the ex vivo study, the mean vertical diameter (Dv) of the coagulative necrosis area and the mean transverse diameter (Dt) values were 11.99 mm and 10.96 mm for group A, 12.66 mm and 10.0 mm for group B, and 23.37 mm and 22.10 mm for group C, respectively. For the in vivo study, the mean Dv and Dt values were 12.23 mm and 9.03 mm for group A, and 16.38 mm and 9.52 mm for group B, respectively. No heat-induced damage to the adjacent organs was observed. To our best knowledge, this is the first study to evaluate the performance of the bipolar system in RFA of the adrenal gland. RFA using the new bipolar ablation system is safe and produces a sufficient coagulation area to treat APAs.
KW - aldosterone-producing adenoma
KW - animal study
KW - primary aldosteronism
KW - radiofrequency ablation
KW - secondary hypertension
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U2 - 10.1620/tjem.2022.J110
DO - 10.1620/tjem.2022.J110
M3 - Article
C2 - 36517016
AN - SCOPUS:85146815550
SN - 0040-8727
VL - 259
SP - 127
EP - 133
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
IS - 2
ER -