TY - JOUR
T1 - Biosynthetic Study on Antihypercholesterolemic Agent Phomoidride
T2 - General Biogenesis of Fungal Dimeric Anhydrides
AU - Fujii, Ryuya
AU - Matsu, Yusuke
AU - Minami, Atsushi
AU - Nagamine, Shota
AU - Takeuchi, Ichiro
AU - Gomi, Katsuya
AU - Oikawa, Hideaki
N1 - Publisher Copyright:
© 2015 American Chemical Society.
PY - 2015/11/20
Y1 - 2015/11/20
N2 - To elucidate the general biosynthetic pathway of fungal dimeric anhydrides, a gene cluster for the biosynthesis of the antihy-percholesterolemic agent phomoidride was identified by heterologous expression of candidate genes encoding the highly reducing polyketide synthase, alkylcitrate synthase (ACS), and alkylcitrate dehydratase (ACDH). An in vitro analysis of ACS and ACDH revealed that they give rise to anhydride monomers. Based on the established monomer biosynthesis, we propose a general biogenesis of dimeric anhydrides involving a single donor unit and four acceptor units.
AB - To elucidate the general biosynthetic pathway of fungal dimeric anhydrides, a gene cluster for the biosynthesis of the antihy-percholesterolemic agent phomoidride was identified by heterologous expression of candidate genes encoding the highly reducing polyketide synthase, alkylcitrate synthase (ACS), and alkylcitrate dehydratase (ACDH). An in vitro analysis of ACS and ACDH revealed that they give rise to anhydride monomers. Based on the established monomer biosynthesis, we propose a general biogenesis of dimeric anhydrides involving a single donor unit and four acceptor units.
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U2 - 10.1021/acs.orglett.5b02934
DO - 10.1021/acs.orglett.5b02934
M3 - Article
C2 - 26558485
AN - SCOPUS:84948187292
VL - 17
SP - 5658
EP - 5661
JO - Organic Letters
JF - Organic Letters
SN - 1523-7060
IS - 22
ER -