Abstract
To elucidate the general biosynthetic pathway of fungal dimeric anhydrides, a gene cluster for the biosynthesis of the antihy-percholesterolemic agent phomoidride was identified by heterologous expression of candidate genes encoding the highly reducing polyketide synthase, alkylcitrate synthase (ACS), and alkylcitrate dehydratase (ACDH). An in vitro analysis of ACS and ACDH revealed that they give rise to anhydride monomers. Based on the established monomer biosynthesis, we propose a general biogenesis of dimeric anhydrides involving a single donor unit and four acceptor units.
| Original language | English |
|---|---|
| Pages (from-to) | 5658-5661 |
| Number of pages | 4 |
| Journal | Organic letters |
| Volume | 17 |
| Issue number | 22 |
| DOIs | |
| Publication status | Published - 2015 Nov 20 |
ASJC Scopus subject areas
- Biochemistry
- Physical and Theoretical Chemistry
- Organic Chemistry
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Fujii, R., Matsu, Y., Minami, A., Nagamine, S., Takeuchi, I., Gomi, K., & Oikawa, H. (2015). Biosynthetic Study on Antihypercholesterolemic Agent Phomoidride: General Biogenesis of Fungal Dimeric Anhydrides. Organic letters, 17(22), 5658-5661. https://doi.org/10.1021/acs.orglett.5b02934