Biosynthetic Study on Antihypercholesterolemic Agent Phomoidride: General Biogenesis of Fungal Dimeric Anhydrides

Ryuya Fujii, Yusuke Matsu, Atsushi Minami, Shota Nagamine, Ichiro Takeuchi, Katsuya Gomi, Hideaki Oikawa

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

To elucidate the general biosynthetic pathway of fungal dimeric anhydrides, a gene cluster for the biosynthesis of the antihy-percholesterolemic agent phomoidride was identified by heterologous expression of candidate genes encoding the highly reducing polyketide synthase, alkylcitrate synthase (ACS), and alkylcitrate dehydratase (ACDH). An in vitro analysis of ACS and ACDH revealed that they give rise to anhydride monomers. Based on the established monomer biosynthesis, we propose a general biogenesis of dimeric anhydrides involving a single donor unit and four acceptor units.

Original languageEnglish
Pages (from-to)5658-5661
Number of pages4
JournalOrganic letters
Volume17
Issue number22
DOIs
Publication statusPublished - 2015 Nov 20

ASJC Scopus subject areas

  • Biochemistry
  • Physical and Theoretical Chemistry
  • Organic Chemistry

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