Biosynthesis of various types of collagen by human hepatoma cells in vitro

Ryojin Uchino, Takahiko Nohara, Eiichi Okamoto, Manabu Fukumoto, Osamu Midorikawa

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)


A cloned human hepatoma cell line (HH2-1) produced and formed collagen fibers in vitro. The relative rate of collagen synthesis by the cells was increased with an enhancement of the cell density. An analysis of the components of the collagen using sodium dodecyl sulfatepolyacrylamide gel electrophoresis revealed that the cells synthesized interstitial collagen, types I and III, and other collagenous proteins. Thus, human hepatoma cells may play an important role in the formation of stromal collagen in the tumor.

Original languageEnglish
Pages (from-to)229-236
Number of pages8
JournalVirchows Archiv B Cell Pathology Including Molecular Pathology
Issue number1
Publication statusPublished - 1985 Jan 1


  • Collagen
  • Hepatoma
  • Liver cell carcinoma

ASJC Scopus subject areas

  • Pathology and Forensic Medicine


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