Biosensors for the Detection of OP Nerve Agents

Jun Ichi Anzai

Research output: Chapter in Book/Report/Conference proceedingChapter

8 Citations (Scopus)


This chapter reviews recent studies of biosensors for detecting organophosphorus (OP) nerve agents. Different detection modes using different enzymes and combinations of them are applicable to constructing OP biosensors using electrochemical principles. Among them, use of the organophosphorus hydrolase (OPH) enzyme is superior to other protocols because OPH-based biosensors directly detect OP compounds in a single step as compared to the inhibition-mode biosensors based on cholinesterase (ChE) and ChE-choline oxidase (ChOx) enzymes, which require two-step operation. One advantage of electrochemical biosensors in OP detection is that a portable device can easily be prepared for in-field analysis. Easy biosensor operation is another benefit when compared to chromatographic or spectroscopic measurements. Therefore, biosensors have a high potential for fast on-site screening of OP nerve agents.

Original languageEnglish
Title of host publicationHandbook of Toxicology of Chemical Warfare Agents
Subtitle of host publicationSecond Edition
PublisherElsevier Inc.
Number of pages10
ISBN (Print)9780128001592
Publication statusPublished - 2015 Jan 21


  • Acetylcholine esterase
  • Biosensor
  • Chemical warfare agents
  • Electrochemical sensor
  • Enzyme sensor
  • Nerve agents
  • Pesticides

ASJC Scopus subject areas

  • Medicine(all)


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