TY - JOUR
T1 - Biosensing properties of titanate-nanotube films
T2 - Selective detection of dopamine in the presence of ascorbate and uric acid
AU - Liu, Aihua
AU - Wei, Mingdeng
AU - Honma, Itaru
AU - Zhou, Haoshen
PY - 2006/2/3
Y1 - 2006/2/3
N2 - A novel strategy based on titanate nanotubes (TNTs) for developing an electrochemical biosensor is proposed. Stable TNT films are fabricated on glassy carbon (GC) electrodes by a casting technique. Cyclic voltammetry, electrochemical impedance spectrometry, and linear-sweep voltammetry are used to characterize the TNT membrane-covered GC electrodes (TNT/GCs). The TNT film is shown to demonstrate selectivity by charge exclusion. The TNT film is also shown to be capable of improving the mass transport to the electrode surface and electron transfer between dopamine (DA) and the electrode. Therefore, DA exhibits a quasireversible electrochemical reaction at the TNT/GC electrode. The voltammetric signal of DA is well resolved from those of ascorbate (AA) and uric acid (UA) at the TNT/GC electrode; therefore, DA can be selectively detected in the presence of a large excess of AA and UA at physiological pH. The linear calibration curve for DA is obtained over the concentration range 0.1-30 μM in a physiological solution that contains 0.1 mM AA and 0.3 mM UA.
AB - A novel strategy based on titanate nanotubes (TNTs) for developing an electrochemical biosensor is proposed. Stable TNT films are fabricated on glassy carbon (GC) electrodes by a casting technique. Cyclic voltammetry, electrochemical impedance spectrometry, and linear-sweep voltammetry are used to characterize the TNT membrane-covered GC electrodes (TNT/GCs). The TNT film is shown to demonstrate selectivity by charge exclusion. The TNT film is also shown to be capable of improving the mass transport to the electrode surface and electron transfer between dopamine (DA) and the electrode. Therefore, DA exhibits a quasireversible electrochemical reaction at the TNT/GC electrode. The voltammetric signal of DA is well resolved from those of ascorbate (AA) and uric acid (UA) at the TNT/GC electrode; therefore, DA can be selectively detected in the presence of a large excess of AA and UA at physiological pH. The linear calibration curve for DA is obtained over the concentration range 0.1-30 μM in a physiological solution that contains 0.1 mM AA and 0.3 mM UA.
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U2 - 10.1002/adfm.200500202
DO - 10.1002/adfm.200500202
M3 - Article
AN - SCOPUS:32244449257
VL - 16
SP - 371
EP - 376
JO - Advanced Functional Materials
JF - Advanced Functional Materials
SN - 1616-301X
IS - 3
ER -