Biosensing properties of titanate-nanotube films: Selective detection of dopamine in the presence of ascorbate and uric acid

Aihua Liu, Mingdeng Wei, Itaru Honma, Haoshen Zhou

Research output: Contribution to journalArticlepeer-review

159 Citations (Scopus)

Abstract

A novel strategy based on titanate nanotubes (TNTs) for developing an electrochemical biosensor is proposed. Stable TNT films are fabricated on glassy carbon (GC) electrodes by a casting technique. Cyclic voltammetry, electrochemical impedance spectrometry, and linear-sweep voltammetry are used to characterize the TNT membrane-covered GC electrodes (TNT/GCs). The TNT film is shown to demonstrate selectivity by charge exclusion. The TNT film is also shown to be capable of improving the mass transport to the electrode surface and electron transfer between dopamine (DA) and the electrode. Therefore, DA exhibits a quasireversible electrochemical reaction at the TNT/GC electrode. The voltammetric signal of DA is well resolved from those of ascorbate (AA) and uric acid (UA) at the TNT/GC electrode; therefore, DA can be selectively detected in the presence of a large excess of AA and UA at physiological pH. The linear calibration curve for DA is obtained over the concentration range 0.1-30 μM in a physiological solution that contains 0.1 mM AA and 0.3 mM UA.

Original languageEnglish
Pages (from-to)371-376
Number of pages6
JournalAdvanced Functional Materials
Volume16
Issue number3
DOIs
Publication statusPublished - 2006 Feb 3
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics

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