Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins

Michinori Tanaka, Kazumi Kajiwara, Rei Tokiwa, Kentaro Watanabe, Hiroaki Ohno, Hiroko Tsutsumi, Yoji Hata, Kazuki Izumi, Eiichi Kodama, Masao Matsuoka, Shinya Oishi, Nobutaka Fujii

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

Bioorganic synthesis of N- and C-terminal end-capped peptides by two simultaneous S-cyanocysteinemediated cleavages of recombinant proteins is described. This approach is demonstrated in the preparation of anti-HIV fusion inhibitory peptides.

Original languageEnglish
Pages (from-to)7487-7492
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume17
Issue number21
DOIs
Publication statusPublished - 2009 Nov 1
Externally publishedYes

Keywords

  • Bioorganic synthesis
  • End-capped peptide
  • Fusion inhibitor
  • HIV-1

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Fingerprint

Dive into the research topics of 'Bioorganic synthesis of end-capped anti-HIV peptides by simultaneous cyanocysteine-mediated cleavages of recombinant proteins'. Together they form a unique fingerprint.

Cite this