Biomimetic tissues on a chip for drug discovery

Amir M. Ghaemmaghami, Matthew J. Hancock, Helen Harrington, Hirokazu Kaji, Ali Khademhosseini

Research output: Contribution to journalReview articlepeer-review

244 Citations (Scopus)

Abstract

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.

Original languageEnglish
Pages (from-to)173-181
Number of pages9
JournalDrug Discovery Today
Volume17
Issue number3-4
DOIs
Publication statusPublished - 2012 Feb

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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