Biomimetic self-assembly of calcium phosphate templated by PNIPAAm nanogels for sustained smart drug delivery

Jun Shi, Wenyan Qi, Gefei Li, Shaokui Cao

Research output: Contribution to journalArticle

21 Citations (Scopus)

Abstract

Poly(N-isopropylacrylamide) (PNIPAAm)/calcium phosphate (CaP) hybrid nanocomposites with dual-responsive controlled drug delivery property have been prepared by in-situ biomineralization process. Poly(acrylic acid) (PAA) is used as a crystal growth additive to control the morphology of the hybrid nanocomposites. The interaction between PAA and Ca 2+ contributes to the formation of homogeneous and robust nanocomposites. Vitamin B 2 release behavior is found to be pH- and thermal-responsive. Additionally, the release profiles are sustained with the introduction of CaP, indicating that CaP nanocrystallines could decrease the permeation of the encapsulated drug effectively. The results suggest that the prepared hybrid nanocomposites can be used as smart nanoscale materials for sustained dual-responsive drug delivery.

Original languageEnglish
Pages (from-to)1299-1306
Number of pages8
JournalMaterials Science and Engineering C
Volume32
Issue number5
DOIs
Publication statusPublished - 2012 Jul 1

Keywords

  • Biomimetic
  • Nanocomposites
  • Self-assembly
  • Smart drug delivery
  • pH/temperature responsive

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanics of Materials
  • Mechanical Engineering

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