Biomimetic phosphorylcholine polymer grafting from polydimethylsiloxane surface using photo-induced polymerization

Tatsuro Goda, Tomohiro Konno, Madoka Takai, Toru Moro, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

193 Citations (Scopus)

Abstract

The biomimetic synthetic phospholipid polymer containing a phosphorylcholine group, 2-methacryloyloxyethyl phosphorylcholine (MPC), has improved the surface property of biomaterials. Both hydrophilic and anti-biofouling surfaces were prepared on polydimethylsiloxane (PDMS) with MPC grafted by surface-initiated photo-induced radical polymerization. Benzophenone was used as the photoinitiator. The quantity of the adsorbed initiator on PDMS was determined by UV absorption and ellipsometry. The poly(MPC)-grafted PDMS surfaces were characterized by XPS, ATR-FTIR and static water contact angle (SCA) measurements. The SCA on PDMS decreased from 115° to 25° after the poly(MPC) grafting. The in vitro single protein adsorption on the poly(MPC)-grafted PDMS decreased 50-75% compared to the unmodified PDMS. The surface friction of the poly(MPC)-grafted PDMS was lower than the unmodified PDMS under wet conditions. The oxygen permeability of the poly(MPC)-grafted PDMS was as high as the unmodified PDMS. The tensile property of PDMS was maintained at about 90% of the ultimate stress and strain after the poly(MPC) grafting. The surface-modified PDMS is expected to be a novel medical elastomer which possesses an excellent surface hydrophilicity, anti-biofouling property, oxygen permeability and tensile property.

Original languageEnglish
Pages (from-to)5151-5160
Number of pages10
JournalBiomaterials
Volume27
Issue number30
DOIs
Publication statusPublished - 2006 Oct
Externally publishedYes

Keywords

  • Friction
  • Oxygen permeation
  • Phosphorylcholine
  • Polydimethylsiloxane
  • Protein adsorption
  • Wettability

ASJC Scopus subject areas

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

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