Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

Wei Zhang; Xiao Juan Luo; Li Na Niu; Hong Ye Yang; Cynthia K.Y. Yiu; Tian Da Wang; Li Qun Zhou; Jing Mao; Cui Huang; David H. Pashley; Franklin R. Tay

doi:10.1038/srep11199

Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

Wei Zhang, Xiao Juan Luo, Li Na Niu, Hong Ye Yang, Cynthia K.Y. Yiu, Tian Da Wang, Li Qun Zhou, Jing Mao, Cui Huang, David H. Pashley, Franklin R. Tay

Research output: Contribution to journal › Article › peer-review

35 Citations (Scopus)

Abstract

Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

Original language	English
Article number	11199
Journal	Scientific reports
Volume	5
DOIs	https://doi.org/10.1038/srep11199
Publication status	Published - 2015 Jun 8
Externally published	Yes

ASJC Scopus subject areas

General

Access to Document

10.1038/srep11199

Cite this

@article{274b93e5a78544b1a1b33eabe315e4a3,

title = "Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers",

abstract = "Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.",

author = "Wei Zhang and Luo, {Xiao Juan} and Niu, {Li Na} and Yang, {Hong Ye} and Yiu, {Cynthia K.Y.} and Wang, {Tian Da} and Zhou, {Li Qun} and Jing Mao and Cui Huang and Pashley, {David H.} and Tay, {Franklin R.}",

note = "Funding Information: This work was supported by grant R01 DE015306-06 from NIDCR, grant 2015AA020942 from National High Technology Research and Development Program of China and grant 81400555 from NSFC. The authors thank Mr. Frankie Chan (University of Hong Kong) for performing STEM-EDX mapping.",

year = "2015",

month = jun,

day = "8",

doi = "10.1038/srep11199",

language = "English",

volume = "5",

journal = "Scientific Reports",

issn = "2045-2322",

publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

AU - Zhang, Wei

AU - Luo, Xiao Juan

AU - Niu, Li Na

AU - Yang, Hong Ye

AU - Yiu, Cynthia K.Y.

AU - Wang, Tian Da

AU - Zhou, Li Qun

AU - Mao, Jing

AU - Huang, Cui

AU - Pashley, David H.

AU - Tay, Franklin R.

N1 - Funding Information: This work was supported by grant R01 DE015306-06 from NIDCR, grant 2015AA020942 from National High Technology Research and Development Program of China and grant 81400555 from NSFC. The authors thank Mr. Frankie Chan (University of Hong Kong) for performing STEM-EDX mapping.

PY - 2015/6/8

Y1 - 2015/6/8

N2 - Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

AB - Limited continuous replenishment of the mineralization medium is a restriction for in-situ solution-based remineralization of hypomineralized body tissues. Here, we report a process that generated amine-functionalized mesoporous silica nanoparticles for sustained release of biomimetic analog-stabilized amorphous calcium phosphate precursors. Both two-dimensional and three-dimensional collagen models can be intrafibrillarly mineralized with these released fluidic intermediate precursors. This represents an important advance in the translation of biomineralization concepts into regimes for in-situ remineralization of bone and teeth.

UR - http://www.scopus.com/inward/record.url?scp=84930960519&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84930960519&partnerID=8YFLogxK

U2 - 10.1038/srep11199

DO - 10.1038/srep11199

M3 - Article

C2 - 26053330

AN - SCOPUS:84930960519

SN - 2045-2322

VL - 5

JO - Scientific Reports

JF - Scientific Reports

M1 - 11199

ER -

Biomimetic intrafibrillar mineralization of type i collagen with intermediate precursors-loaded mesoporous carriers

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this