Biomembrane mimetic anti-bioadsorption interface constructed for microfluidic devices

Yan Xu, Madoka Takai, Tomohiro Konno, Kazuhiko Ishihara

Research output: Contribution to conferencePaper

Abstract

A negatively charged phospholipid polymer PMBSSi oriented to quartz/glass was newly designed and synthesized. Several kinds of proteins, their concentration were 1 % human plasma level, were used to evaluate the coating effect. After PMBSSi coating, the protein adsorptions on all the plates, quartz or glass, were decreased at least several times and the maximum is more than 20 times. Moreover, the absolute amounts of remained proteins on the coating surfaces were at a quite low level, nearly all below 0.5μg/cm2. As a conclusion, PMBSSi coating have more potential to be applied in those protein chips whose inner surface not only need anti-adsorption but also need a certain amount of charge to realize or improve special functions such as EOF effect.

Original languageEnglish
Number of pages1
Publication statusPublished - 2006 Oct 19
Externally publishedYes
Event55th SPSJ Annual Meeting - Nagoya, Japan
Duration: 2006 May 242006 May 26

Other

Other55th SPSJ Annual Meeting
CountryJapan
CityNagoya
Period06/5/2406/5/26

Keywords

  • Anti-bioadsorption
  • Biomembrane-mimetic
  • Glass
  • Microfluidic
  • Negatively charged phospholipid polymer
  • Quartz

ASJC Scopus subject areas

  • Engineering(all)

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  • Cite this

    Xu, Y., Takai, M., Konno, T., & Ishihara, K. (2006). Biomembrane mimetic anti-bioadsorption interface constructed for microfluidic devices. Paper presented at 55th SPSJ Annual Meeting, Nagoya, Japan.