Biological evaluation of 5-Methyl-branched-chain ω-[18F]fluorofatty acid: A potential myocardial imaging tracer for positron emission tomography

Toshihiro Takahashi, Shin Ichi Nishimura, Tatsuo Ido, Ki Ichi Ishiwata, Ren Iwata

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

5-Methyl-17-[18F]fIuoroheptadecanoic acid (5-MFHA) has been proposed as a new myocardial imaging tracer for positron emission tomography (PET), containing methyl-branching at the odd-numbered position, except the 3-position. To compare the site of methyl-branching of fatty acids on the contribution to myocardial imaging, the biological evaluation of 5-MFHA - using accumulation studies, metabolic studies, and PET studies of the heart muscle - was investigated. In the comparative biodistribution studies for 16-[18F]fluoropalmitic acid (FPA), 3-methyl-17-[18F]fluoroheptadecanoic acid (3-MFHA) and 5-MFHA, the initial myocardial uptake of 5-MFHA (2.64 [% dose/g tissue]) was relatively high between those of FPA and 3-MFHA (3.45 and 1.58, respectively), and the washout from myocardium of 5-MFHA was midway between those of FPA and 3-MFHA. In the lipid analysis studies, 5-MFHA was mainly metabolized to triglycerides in the myocardium, and its metabolic pattern was similar to that of straight-chain fatty acids (FPA). In the PET studies using 5-MFHA in canines, good myocardial images were obtained for up to 30 min after injection.

Original languageEnglish
Pages (from-to)303-308
Number of pages6
JournalNuclear Medicine and Biology
Volume23
Issue number3
DOIs
Publication statusPublished - 1996 Apr
Externally publishedYes

Keywords

  • 5-Methyl-17-[F]fluoroheptadecanoic acid
  • Labeled fatty acids
  • Methyl branching
  • Myocardial imaging
  • Positron emission tomography
  • β-oxidation

ASJC Scopus subject areas

  • Molecular Medicine
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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