Abstract
The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.
| Original language | English |
|---|---|
| Pages (from-to) | 1003-1010 |
| Number of pages | 8 |
| Journal | Nippon juigaku zasshi. The Japanese journal of veterinary science |
| Volume | 51 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1989 Jan 1 |
ASJC Scopus subject areas
- Medicine(all)
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Isogai, H., Isogai, E., Fujii, N., Oguma, K., Chang, K. L., Deguchi, E., Takano, K., Hayashi, M., & Namioka, S. (1989). Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages. Nippon juigaku zasshi. The Japanese journal of veterinary science, 51(5), 1003-1010. https://doi.org/10.1292/jvms1939.51.1003