TY - JOUR
T1 - Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.
AU - Isogai, H.
AU - Isogai, E.
AU - Fujii, N.
AU - Oguma, K.
AU - Chang, K. L.
AU - Deguchi, E.
AU - Takano, K.
AU - Hayashi, M.
AU - Namioka, S.
N1 - Copyright:
Copyright 2017 Medline is the source for the citation and abstract of this record.
PY - 1989/10
Y1 - 1989/10
N2 - The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.
AB - The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.
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U2 - 10.1292/jvms1939.51.1003
DO - 10.1292/jvms1939.51.1003
M3 - Article
C2 - 2481763
AN - SCOPUS:0024746166
VL - 51
SP - 1003
EP - 1010
JO - Journal of Veterinary Medical Science
JF - Journal of Veterinary Medical Science
SN - 0916-7250
IS - 5
ER -