Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.

H. Isogai; E. Isogai; N. Fujii; K. Oguma; K. L. Chang; E. Deguchi; K. Takano; M. Hayashi; S. Namioka

doi:10.1292/jvms1939.51.1003

Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.

H. Isogai, E. Isogai, N. Fujii, K. Oguma, K. L. Chang, E. Deguchi, K. Takano, M. Hayashi, S. Namioka

AGR - Bioscience and Biotechnology for Future Bioindustries

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Abstract

The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.

Original language	English
Pages (from-to)	1003-1010
Number of pages	8
Journal	Nippon juigaku zasshi. The Japanese journal of veterinary science
Volume	51
Issue number	5
DOIs	https://doi.org/10.1292/jvms1939.51.1003
Publication status	Published - 1989 Oct

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Medicine(all)

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Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages. / Isogai, H.; Isogai, E.; Fujii, N.; Oguma, K.; Chang, K. L.; Deguchi, E.; Takano, K.; Hayashi, M.; Namioka, S.

In: Nippon juigaku zasshi. The Japanese journal of veterinary science, Vol. 51, No. 5, 10.1989, p. 1003-1010.

Research output: Contribution to journal › Article › peer-review

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abstract = "The immunopotentiating activities of lipopolysaccharide from Achromobacter stenohalis (A-LPS) were examined. A-LPS was structurally atypical and gave no endotoxin shock in A-LPS-inoculated mice. Analysis in vitro showed that A-LPS was a potent activator of both macrophages and B-lymphocytes. After macrophage stimulation with A-LPS, interleukin-1 (IL-1) secretion, interferon (IFN) production and chemiluminescence (CL) response were induced. A-LPS was a potent mitogen for spleen lymphocytes. However, induction of interleukin-2 (IL-2) secretion in T lymphocytes was not observed. These activities of A-LPS were similar to or higher than that of enterobacterial LPS.",

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AU - Fujii, N.

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AU - Chang, K. L.

AU - Deguchi, E.

AU - Takano, K.

AU - Hayashi, M.

AU - Namioka, S.

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Biological effects of lipopolysaccharide from Achromobacter stenohalis on lymphocytes and macrophages.

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