Biological behavior of hat-stacked carbon nanofibers in the subcutaneous tissue in rats

Atsuro Yokoyama, Yoshinori Sato, Yoshinobu Nodasaka, Satoru Yamamoto, Takao Kawasaki, Masanobu Shindoh, Takao Kongo, Tsukasa Akasaka, Motohiro Uo, Fumio Watari, Kazuyuki Tohji

Research output: Contribution to journalArticlepeer-review

111 Citations (Scopus)

Abstract

The tissue response to hat-stacked carbon nanofibers (H-CNFs) was evaluated. H-CNFs were implanted in the subcutaneous tissue of rats. Histological and ultrastructural investigations were carried out by transmission electron microscopy. Although many macrophages and foreign body giant cells were seen around H-CNFs, no severe inflammatory response such as necrosis was observed. Some H-CNFs were observed in lysosomal vacuoles of phagocytes. These results showed that H-CNFs were not strong prophlogistic substances and were englobed in vivo.

Original languageEnglish
Pages (from-to)157-161
Number of pages5
JournalNano Letters
Volume5
Issue number1
DOIs
Publication statusPublished - 2005 Jan 1

ASJC Scopus subject areas

  • Bioengineering
  • Chemistry(all)
  • Materials Science(all)
  • Condensed Matter Physics
  • Mechanical Engineering

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