Biodistribution and radiation absorbed dose of (N-methyl[ 11 C])pyrilamine: a histamine H-1 receptor radiotracer

Kazuhiko Yanai, Robert F. Dannals, Alan A. Wilson, Hayden T. Ravert, Ursula Scheffel, Shuji Tanada, Henry N. Wagner

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

The in vivo biodistribution for (N-methyl[ 11 C])pyrilamine in mice is reported for various times after i.v. bolus injection, together with estimates of the radiation absorbed dose for the same radiotracer in man. More than 60% of the injected dose was excreted via the kidneys in urine after 90 min post injection. The brain regional distribution in mice showed a favorable hypothalamus-to-cerebellum ratio, indicative of H-1 receptor binding, encouraging in vivo histamine H-1 receptor imaging studies in man.

Original languageEnglish
Pages (from-to)361-363
Number of pages3
JournalInternational Journal of Radiation Applications and Instrumentation.
Volume16
Issue number4
DOIs
Publication statusPublished - 1989 Jan 1
Externally publishedYes

ASJC Scopus subject areas

  • Medicine(all)

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