Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin

Akari Takeuchi; Chikara Ohtsuki; Masanobu Kamitakahara; Shin Ichi Ogata; Masao Tanihara; Toshiki Miyazaki; Masao Yamazaki; Yoshiaki Furutani; Hisao Kinoshita

doi:10.4028/0-87849-961-x.329

Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin

Akari Takeuchi, Chikara Ohtsuki, Masanobu Kamitakahara, Shin Ichi Ogata, Masao Tanihara, Toshiki Miyazaki, Masao Yamazaki, Yoshiaki Furutani, Hisao Kinoshita

Research output: Contribution to journal › Article › peer-review

6 Citations (Scopus)

Abstract

Porous α-tricalcium phosphate (α-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of ß-TCP at high temperature. However, the solubility of α-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the α-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of α-TCP porous body coated with silk scricin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for α-TCP coated with sericin than for mere α-TCP. The α-TCP porous body coated with sericin is expected as a material that show less degradation than mere α-TCP, and may result in suitable bone repair.

Original language	English
Pages (from-to)	329-332
Number of pages	4
Journal	Key Engineering Materials
Volume	284-286
DOIs	https://doi.org/10.4028/0-87849-961-x.329
Publication status	Published - 2005 Jan 1
Externally published	Yes

Keywords

Biodegradation
Coating
Porous body
Silk sericin
α-tricalcium phosphate α-TCP

ASJC Scopus subject areas

Materials Science(all)
Mechanics of Materials
Mechanical Engineering

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10.4028/0-87849-961-x.329

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title = "Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin",

abstract = "Porous α-tricalcium phosphate (α-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of {\ss}-TCP at high temperature. However, the solubility of α-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the α-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of α-TCP porous body coated with silk scricin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for α-TCP coated with sericin than for mere α-TCP. The α-TCP porous body coated with sericin is expected as a material that show less degradation than mere α-TCP, and may result in suitable bone repair.",

keywords = "Biodegradation, Coating, Porous body, Silk sericin, α-tricalcium phosphate α-TCP",

author = "Akari Takeuchi and Chikara Ohtsuki and Masanobu Kamitakahara and Ogata, {Shin Ichi} and Masao Tanihara and Toshiki Miyazaki and Masao Yamazaki and Yoshiaki Furutani and Hisao Kinoshita",

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doi = "10.4028/0-87849-961-x.329",

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T1 - Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin

AU - Takeuchi, Akari

AU - Ohtsuki, Chikara

AU - Kamitakahara, Masanobu

AU - Ogata, Shin Ichi

AU - Tanihara, Masao

AU - Miyazaki, Toshiki

AU - Yamazaki, Masao

AU - Furutani, Yoshiaki

AU - Kinoshita, Hisao

PY - 2005/1/1

Y1 - 2005/1/1

N2 - Porous α-tricalcium phosphate (α-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of ß-TCP at high temperature. However, the solubility of α-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the α-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of α-TCP porous body coated with silk scricin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for α-TCP coated with sericin than for mere α-TCP. The α-TCP porous body coated with sericin is expected as a material that show less degradation than mere α-TCP, and may result in suitable bone repair.

AB - Porous α-tricalcium phosphate (α-TCP) ceramics are attractive as a novel bioresorbable material for bone repair, since they can be easily fabricated through conventional sintering of ß-TCP at high temperature. However, the solubility of α-TCP is too high to keep its body until the bone defect is repaired completely. Coating of the α-TCP porous body with organic polymer is a way to reduce the degradation rate. In the present study, biodegradation of α-TCP porous body coated with silk scricin was evaluated in vivo. Bone repair at the defect made in rabbit tibia was nearly completed after 4 weeks. Higher density of cortical bone was estimated for α-TCP coated with sericin than for mere α-TCP. The α-TCP porous body coated with sericin is expected as a material that show less degradation than mere α-TCP, and may result in suitable bone repair.

KW - Biodegradation

KW - Coating

KW - Porous body

KW - Silk sericin

KW - α-tricalcium phosphate α-TCP

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VL - 284-286

SP - 329

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JO - Key Engineering Materials

JF - Key Engineering Materials

ER -

Biodegradation of porous alpha-tricalcium phosphate coated with silk sericin

Abstract

Keywords

ASJC Scopus subject areas

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