TY - JOUR
T1 - Biodegradable Porous Microneedles for an Electric Skin Patch
AU - Abe, Hiroya
AU - Matsui, Yuuya
AU - Kimura, Natsumi
AU - Nishizawa, Matsuhiko
N1 - Funding Information:
This work was partly supported by Tohoku University Frontier Research program (FRiD) and by Grant‐in‐Aids for Scientific Research A (18H04158), Young Scientists (19K15598) and Challenging Exploratory Research (20K21877) from the Ministry of Education, Culture, Sports, Science and Technology, Japan.
Publisher Copyright:
© 2021 Wiley-VCH GmbH
PY - 2021/9
Y1 - 2021/9
N2 - An array of porous microneedles (PMNs) made of biodegradable poly(lactic-co-glycolic acid) (PLGA) is fabricated by a combination of molding and freeze-drying methods. The optimized mixture of PLGA and 1,4-dioxane is poured into a mold of a microneedle array, followed by the freezing and sublimation of the frozen particles of 1,4-dioxane, a procedure that left an interconnecting porous structure in the PLGA with a porosity around 50%. The mechanical strength of the PMN made of PLGA (PLGA-PMN) is reinforced by modification with carboxymethylcellulose (CMC), resulting in sufficient strength enough for insertion into an excised porcine skin. The transdermal resistance is significantly decreased by the CMC-modified PLGA-PMN, which would improve the efficiency and safety of DC current-based transdermal techniques, including the electrical monitoring of the skin condition and iontophoresis for drug delivery and medical diagnosis.
AB - An array of porous microneedles (PMNs) made of biodegradable poly(lactic-co-glycolic acid) (PLGA) is fabricated by a combination of molding and freeze-drying methods. The optimized mixture of PLGA and 1,4-dioxane is poured into a mold of a microneedle array, followed by the freezing and sublimation of the frozen particles of 1,4-dioxane, a procedure that left an interconnecting porous structure in the PLGA with a porosity around 50%. The mechanical strength of the PMN made of PLGA (PLGA-PMN) is reinforced by modification with carboxymethylcellulose (CMC), resulting in sufficient strength enough for insertion into an excised porcine skin. The transdermal resistance is significantly decreased by the CMC-modified PLGA-PMN, which would improve the efficiency and safety of DC current-based transdermal techniques, including the electrical monitoring of the skin condition and iontophoresis for drug delivery and medical diagnosis.
KW - biodegradable polymers
KW - microneedles
KW - skin patches
KW - transdermal drug delivery
UR - http://www.scopus.com/inward/record.url?scp=85111813594&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85111813594&partnerID=8YFLogxK
U2 - 10.1002/mame.202100171
DO - 10.1002/mame.202100171
M3 - Article
AN - SCOPUS:85111813594
SN - 1438-7492
VL - 306
JO - Macromolecular Materials and Engineering
JF - Macromolecular Materials and Engineering
IS - 9
M1 - 2100171
ER -