Biodegradable polymer films for releasing nanovehicles containing sirolimus Biodegradable polymer containing nanovehicles with sirolimus Hyung Il Kim et al.

Hyung Il Kim, Madoka Takai, Tomohiro Konno, Ryosuke Matsuno, Kazuhiko Ishihara

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

To obtain novel biodegradable sirolimus-releasing polymer films that could release nanovehicles incorporating sirolimus, polyester, a water-soluble amphiphilic phospholipid polymer, and sirolimus were blended. The sirolimus-releasing polymer films were characterized by scanning electron microscopy and differential scanning calorimetry. Nanovehicles were formed with the phospholipid polymer chains and could be released from the sirolimus-releasing polymer films. The hydrodynamic diameter of the nanovehicles in phosphate-buffered saline was smaller than 20nm. The nanovehicles substantially enhanced the carrier-mediated delivery of sirolimus and attenuated its degradation product. This study demonstrates that the delivery of sirolimus was enhanced by nanovehicles released from sirolimus-eluting materials.

Original languageEnglish
Pages (from-to)183-188
Number of pages6
JournalDrug Delivery
Volume16
Issue number4
DOIs
Publication statusPublished - 2009

Keywords

  • 2-methacryloyloxyethyl phosphorylcholine polymer
  • Biodegradable polymer film
  • Drug-eluting stents
  • Nanovehicles
  • Sirolimus

ASJC Scopus subject areas

  • Pharmaceutical Science

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