TY - JOUR
T1 - Biodegradable hydrogels for bone regeneration through growth factor release
AU - Tabata, Yasuhiko
AU - Yamamoto, Masaya
AU - Ikada, Yoshito
N1 - Funding Information:
This research was supported by a grant of "Research for the Future" Program from the Japan Society for the Promotion of Science (JSPS-RFTF96100203).
PY - 1998/6
Y1 - 1998/6
N2 - For successful tissue regeneration, growth factors should be released over a long period of time at the site of action, but their in vivo half-life time is very short. The sustained release of growth factors could be achieved by taking advantage of biodegradable hydrogels prepared from acidic gelatin with an isoelectric point (IEP) of 5.0. When mixed with this negatively charged gelatin, positively charged growth factors ionically interacted at the neutral pH to form a polyion complex. Gelatin hydrogels were enzymatically degraded in the body with time and the time profile of growth factor release was in good accordance with that of in vivo hydrogel degradation. This indicates that the growth factor complexed with the acidic gelatin constituting hydrogels was released as a result of their biodegradation. This article briefly overviews the in vivo release of basic fibroblast growth factor (bFGF) and transforming growth factor β1 (TGF-β1) from gelatin hydrogels.
AB - For successful tissue regeneration, growth factors should be released over a long period of time at the site of action, but their in vivo half-life time is very short. The sustained release of growth factors could be achieved by taking advantage of biodegradable hydrogels prepared from acidic gelatin with an isoelectric point (IEP) of 5.0. When mixed with this negatively charged gelatin, positively charged growth factors ionically interacted at the neutral pH to form a polyion complex. Gelatin hydrogels were enzymatically degraded in the body with time and the time profile of growth factor release was in good accordance with that of in vivo hydrogel degradation. This indicates that the growth factor complexed with the acidic gelatin constituting hydrogels was released as a result of their biodegradation. This article briefly overviews the in vivo release of basic fibroblast growth factor (bFGF) and transforming growth factor β1 (TGF-β1) from gelatin hydrogels.
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U2 - 10.1351/pac199870061277
DO - 10.1351/pac199870061277
M3 - Article
AN - SCOPUS:0000195841
SN - 0033-4545
VL - 70
SP - 1277
EP - 1282
JO - Pure and Applied Chemistry
JF - Pure and Applied Chemistry
IS - 6
ER -